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本文研究了侧脑室注入ＬａＣｌ３对大鼠血清中生长系（ＧＨ）、甲状腺素（Ｔ３，Ｔ４）、促甲状腺素（ＴＳＨ）和下丘脑中生长抑素（ＳＳ）的影响。侧脑室注射０００１和００１ｍｏｌ·Ｌ－１ＬａＣｌ３，血清中Ｔ４和ＧＨ含量明显高于对照组（Ｐ＜００５，Ｐ＜００１），０１和０５ｍｏｌ·Ｌ－１ＬａＣｌ３组血清Ｔ４和ＧＨ未见明显变化。侧脑室多次注射０１ｍｏｌ·Ｌ－１ＬａＣｌ３血清ＧＨ，Ｔ３，Ｔ４和ＴＳＨ均明显增加（Ｐ＜００５），０００１ｍｏｌ·Ｌ－１组血清激素无明显变化。在血清激素明显变化动物的下丘脑中ＳＳ含量均明显降低，说明一定量ＬａＣｌ３注入脑室内可促进生长素和甲状腺素的分泌，其作用机制与下丘脑中ＳＳ抑素减少及腺垂体中ＴＳＨ增多有关
This study investigated the effects of intracerebroventricular injection of LaCl3 on growth hormone (GH), thyroxine (T3, T4), thyrotropin (TSH) and somatostatin (SS) in the hypothalamus. Intracerebroventricular injection of 0001 and 001mol·L-1LaCl3, serum T4 and GH levels were significantly higher than the control group (P <0 05, P <0 01), 0 1 and 0 5mol·L- 1LaCl3 serum T4 and GH no significant change. Multiple intracerebroventricular injection of 0.1 mol·L-1 LaCl3 serum GH, T3, T4 and TSH were significantly increased (P <0 05), 0 001mol·L-1 serum hormone did not change significantly. The content of SS in the hypothalamus of animals with significant changes of serum hormone were significantly decreased, indicating that a certain amount of LaCl3 injected into the ventricle can promote the secretion of auxin and thyroxine, and its mechanism of action is related to the decrease of SS in the hypothalamus and the increase of TSH in the pituitary related