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本文报道了非离子型X-CT造影剂碘海醇注射液的制备及动物实验结果。磺海醇的最大吸收波长λ_(max)为244nm。讨论了温度、浓度对磺海醇溶液粘度的影响:粘度随温度的升高而下降,呈负线型相关;粘度随浓度(C)升高而激剧升高,与浓度的四次方呈线性相关:V_(37℃)=472.589[C] ̄4+1.121(r=0.9977)V_(30℃)=663.813[C] ̄4+1.152(r=0.9996)V_(20℃)=1082.953[C] ̄4+1.433(r=0.9982)使用该注射液进行狗的造影实验,获得了清晰的造影图像。
This paper reports the preparation of non-ionic X-CT contrast agent iohexol injection and animal experiments. The maximum absorption wavelength of sulfoalcohol, λ max, is 244 nm. The effects of temperature and concentration on the viscosity of sulfosanol solution are discussed. The viscosity decreases with the increase of temperature and is negatively correlated. The viscosity increases sharply with the increase of concentration (C) Linear correlation: V_ (37 ° C) = 472.589 [C] ¯4 + 1.121 (r = 0.9977) V_ (30 ° C) = 663.813 [C] ¯4 + 1.152 (r = 0.9996) (20 ℃) = 1082.953 [C] ¯4 + 1.433 (r = 0.9982) Using the injection for dog imaging, a clear contrast image was obtained.