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目的:观察疏肝解郁中药对肝郁型特发性真性性早熟(idiopathic central precocious puberty,ICPP)女孩的心理行为状况以及中医证候的影响。方法:对符合诊断标准的38例ICPP女孩予疏肝解郁中药治疗12月,治疗前后采用阿成贝切儿童行为量表(Achenbach’s child behavior check list,CBCL)进行心理行为评估,并与正常对照组比较,同时比较治疗前后中医证候评分及预测身高。结果:肝郁型ICPP女孩治疗前CBCL的抑郁、社交退缩两个因子评分明显高于正常对照组(P<0.05),治疗后CBCL的以上两个因子评分明显低于治疗前水平(P<0.05),治疗后中医证候总评分明显低于治疗前(P<0.01),预测身高明显高于治疗前(P<0.05)。结论:肝郁型ICPP女孩存在一定程度的抑郁、社交退缩的不良情绪和行为,中医药的治疗能有效改善ICPP女孩的中医证候评分及预测身高,同时也可以改善该证型患儿的不良心理情绪和行为。
Objective: To observe the effect of Shugan Jieyu on psychological behavior of idiopathic central precocious puberty (ICPP) girls and TCM syndromes. Methods: Thirty-eight ICPP girls who met the diagnostic criteria were treated with Chinese herbal medicine of Shugan Jieyu for 12 months. The psychological behavioral assessment was performed before and after treatment with Achenbach’s child behavior checklist (CBCL), and compared with the normal control Group comparison, at the same time comparing TCM score and predict height before and after treatment. Results: The scores of depression and social withdrawal before treatment in liver depression ICPP girls were significantly higher than those in normal control group (P <0.05). After treatment, the scores of CBCL above two factors were significantly lower than those before treatment (P <0.05 ). After treatment, the total score of TCM syndromes was significantly lower than that before treatment (P <0.01). The predicted height was significantly higher than that before treatment (P <0.05). Conclusion: ICP-girls with liver depression have a certain degree of depression and social withdrawal with negative emotions and behaviors. The treatment of traditional Chinese medicine can effectively improve the TCM syndrome score and predict the height of ICPP girls, and can also improve the patients with this syndrome Mental emotions and behaviors.