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为探讨胰腺癌组织ＣＤ４４和ｐ２１蛋白表达与其转移特性的关系，以及两者表达的相关性，作者采用针对ＣＤ４４各种变异体的鼠抗人单克隆抗体Ｆ１０－４４－２和ｐ２１蛋白单克隆抗体，对４６例胰腺癌原发灶，１８例胰腺癌淋巴结转移灶和５例胰腺癌肝转移灶进行免疫组化染色。结果胰腺癌转移灶ＣＤ４４和ｐ２１蛋白的阳性染色率显著高于原发灶；有转移的胰腺癌组织ＣＤ４４和ｐ２１的表达均高于无转移者，两者均有显著性差异。相关性检验显示ＣＤ４４阳性组和ｐ２１阳性组有显著的相关性。结果表明：ＣＤ４４或ｐ２１表达阳性的胰腺癌组织，较易发生转移，作者认为ｐ２１蛋白通过引起变异型ＣＤ４４表达升高来促进转移。
To investigate the relationship between the expression of CD44 and p21 protein in pancreatic cancer tissues and their metastasis characteristics, as well as the correlation between the two expressions, the authors used mouse anti-human monoclonal antibodies F10-44-2 and p21 monoclonal antibodies against various variants of CD44. , 46 cases of primary pancreatic cancer, 18 cases of lymph node metastases of pancreatic cancer and 5 cases of liver metastases of pancreatic cancer were immunohistochemically stained. Results The positive staining rates of CD44 and p21 proteins in pancreatic cancer metastases were significantly higher than those in primary lesions. The expressions of CD44 and p21 in metastatic pancreatic cancer tissues were significantly higher than those in non-metastasis pancreatic tissues. There was a significant difference between them. The correlation test showed a significant correlation between the CD44 positive and p21 positive groups. The results showed that pancreatic cancer tissues with positive expression of CD44 or p21 were more likely to undergo metastasis. The authors believe that p21 protein promotes metastasis by causing elevated expression of variant CD44.