Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic strok

• 出 处: Neural Regeneration Research
• 发表日期: 2011年35期
• 关键词: herbal potent Apium targeted inhibiting toxicity neuronal mitochondria oxidative

Dl-3n-butylphthalide is the active component isolated from the seeds of Apium graveolens Linn.A number of pharmacological and clinical studies have proven that dl-3n-butylphthalide is highly potent and multi-targeted with low toxicity and has a long time-window for the treatment of ischemic cerebrovascular disease.The mechanisms underlying dl-3n-butylphthalide include improving mi-tochondrial function and microcirculation,inhibiting apoptosis and reducing oxidative stress.Fur-thermore,dl-3n-butylphthalide may also be promising for the treatment of neurodegenerative dis-eases,such as Alzheimer’s disease,vascular dementia and Parkinson’s disease.

Dl-3n-butylphthalide is the active component isolated from the seeds of Apium graveolens Linn. A number of pharmacological and clinical studies have proven that dl-3n-butylphthalide is highly potent and multi-targeted with low toxicity and has a long time-window for the treatment of ischemic cerebrovascular disease. The mechanisms underlying dl-3n-butylphthalide include improving mi-tochondrial function and microcirculation, inhibiting apoptosis and reducing oxidative stress. Fur-thermore, dl-3n-butylphthalide may also be promising for the treatment of neurodegenerative dis-eases, such as Alzheimer’s disease, vascular dementia and Parkinson’s disease.