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一、前言绒毛外滋养细胞入侵母体子宫组织对胎盘发育和妊娠过程顺利进行必不可少。血管内滋养细胞迁移进入母体螺旋动脉,间质滋养细胞侵入蜕膜,与不同的子宫细胞类型发生作用,如:蜕膜基质细胞、巨噬细胞和子宫自然杀伤细胞(natural killer cell,NK细胞)。与肿瘤不同的是,间质滋养细胞侵袭深度不超过蜕膜和子宫肌层外三分之一。滋养细胞侵袭的程度是由滋养层细胞和母体因素以时空的方式精确调控的。滋养细胞侵入调控失衡会导致各种病
First, the introduction of extravillous trophoblast invasion of maternal uterine tissue on the placental development and pregnancy process is essential. Endovascular trophoblasts migrate into the maternal spiral arteries and stromal trophoblasts invade the decidua and interact with different uterine cell types such as decidual stromal cells, macrophages, and natural killer cells (NK cells) . Unlike tumors, the depth of stromal trophoblast invasion does not exceed one-third of the decidua and myometrium. The degree of trophoblast invasion is precisely controlled by trophoblastic cells and maternal factors spatially and temporally. Trophoblastic invasion imbalance can lead to various diseases