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SD rats were initiated with 10 mg/kg DENA by I.P.injection 18-24 hrs after a 70% hepatectomy(PH).One weeklater,0.05% phenobarbital(PB) were added to drinkingwater(PH+DENA+PB model).Rats were killed at the end ofthe 1st week and at the end of 1st,2nd,3rd,4