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Ion channels are crucial in the generation and modulation of excitability in the nervous system and have been implicated in human epilepsy.Forty-one epilepsyassociated ion channel genes and their mutations are systematically reviewed.In this paper,we analyzed the genotypes,functional alterations (funotypes),and phenotypes of these mutations.Eleven genes featured loss-offunction mutations and six had gain-of-function mutations.Nine genes displayed diversified funotypes,among which a distinct funotype-phenotype correlation was found in SCN1A.These data suggest that the funotype is an essential consideration in evaluating the pathogenicity of mutations and a distinct funotype or funotype-phenotype correlation helps to define the pathogenic potential of a gene.