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本研究对１１名焦炉工和１１名沥青工染色体畸变及血清Ｐ２１蛋白进行了联合检测，接触组染色体畸变及血清Ｐ２１蛋白水平均显著高于对照组（Ｐ＜０．０１），沥青工和焦炉工染色体畸变无显著住差异（Ｐ＞０．０５），沥青工Ｐ２１蛋白水平显著高于焦炉工（Ｐ＜０．０５），有２名沥青工血清Ｐ２１蛋白用性。染色体畸变与血清Ｐ２１蛋白水平无明显直线相关关系。结果提示，Ｐ２１阳性个体有发生用变的潜在危险，接触多环芳烃类物质可以造成染色体损伤和ｒａｓ基因表达的增强，沥青烟气对Ｐ２１蛋白表达水平的升高有较强的作用。
In this study, 11 coke oven workers and 11 asphaltenic chromosome aberrations and serum P21 protein were detected jointly. Chromosome aberration and serum P21 protein level in the contact group were significantly higher than those in the control group (P <0.01) There was no significant difference in chromosome aberration among coke oven workers (P> 0.05). The level of P21 protein in asparagus workers was significantly higher than that in coke oven workers (P <0.05). Chromosome aberration and serum P21 protein level no significant linear correlation. The results suggest that P21-positive individuals have the potential to change with the risk of exposure to polycyclic aromatic hydrocarbons can cause chromosome damage and ras gene expression increased, asphalt fume on P21 protein expression levels have a stronger role.