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目的探讨延髓腹外侧头端区（ｒｏｓｔｒａｌｖｅｎｔｒｏｌａｔｅｒａｌｍｅｄｕｌａ，ＲＶＬＭ）内血管紧张素Ⅱ（ＡｎｇⅡ）在自发性高血压大鼠（ＳＨＲ）血压调节及高血压形成中的作用。方法实验在１６周龄雄性ＳＨＲ大鼠及ＷＫＹ大鼠上进行，氨基甲酸乙酯麻醉，自主呼吸，暴露ＲＶＬＭ，ＲＶＬＭ经Ｌ－谷氨酸及组织学定位，微量注射人工脑脊液、ＡｎｇⅡ和［Ｓａｒ１，Ｔｈｒ８］ＡｎｇⅡ至ＲＶＬＭ，观察给药前后血压、心率的变化。结果在ＳＨＲ及ＷＫＹ大鼠，ＲＶＬＭ单次或重复微量注射人工脑脊液，不引起血压、心率变化。ＲＶＬＭ内微量注射不同剂量的ＡｎｇⅡ，引起血压升高，心率增加。两组实验动物ＲＶＬＭ预先注射［Ｓａｒ１，Ｔｈｒ８］ＡｎｇⅡ可以阻断ＡｎｇⅡ的作用。ＲＶＬＭ微量注射不同剂量的［Ｓａｒ１，Ｔｈｒ８］ＡｎｇⅡ（ｐｍｏｌ：０．１，１．０，１０，１００），则引起血压、心率下降。在ＳＨＲ大鼠，血压下降的幅度值明显大于ＷＫＹ大鼠（ｍｍＨｇ：－１８±４，－２３±５，－２７±６，－３３±６ｖｓ－１１±３，－１３±４，－１７±５，－１９±５），而心率的变化在两组动物中无显著差别（ｂｐｍ：－１３±５，－１７±６，－１８±５，－２０±５ｖｓ－１０±４，?
Objective To investigate the role of angiotensin Ⅱ (Ang Ⅱ) in the regulation of blood pressure and hypertension in spontaneously hypertensive rats (SHR) in rostral ventrolaterallateral head region (RVLM). Methods The experiment was performed on male SHR rats and WKY rats at 16 weeks of age. Urethane anesthesia, spontaneous respiration, exposure of RVLM, localization of RVLM via L-glutamic acid and histology, microinjection of artificial cerebrospinal fluid, AngⅡ and [Sar1 , Thr8] Ang Ⅱ to RVLM, before and after treatment to observe changes in blood pressure, heart rate. Results In SHR and WKY rats, single or repeated microinjection of RVLM into artificial cerebrospinal fluid did not cause changes in blood pressure and heart rate. Microinjection of different doses of Ang II in RVLM causes an increase in blood pressure and an increase in heart rate. Two groups of experimental animals pre-injected with RVLM [Sar1, Thr8] AngⅡ can block the effect of AngⅡ. Microinjection of different doses of [Sar1, Thr8] AngII (pmol: 0.1, 1.0, 10, 100) into RVLM induced a decrease in blood pressure and heart rate. In SHR rats, the magnitude of blood pressure decline was significantly greater than that of WKY rats (mmHg: -18 ± 4, -23 ± 5, -27 ± 6, -33 ± 6 vs -11 ± 3, -13 ± 4, -17 ± 5, -19 ± 5), while changes in heart rate did not differ significantly between the two groups (bpm: -13 ± 5, -17 ± 6, -18 ± 5, -20 ± 5 vs-10 ± 4,