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以免疫组化方法分别对11例儿童复发性喉乳头状瘤手术摘除标本进行P53蛋白及人乳头状瘤病毒抗原（HPV－Ag）检测，结果全部标本（11／11）p53蛋白染色均呈弱阳性，被染色的细胞仅局限于基底上皮细胞，呈散在分布。HPV－Ag染色阳。隆率为64％（7／11）。指出p53基因突变在本病中属频发事件，可能与本病易反复复发的特征有关。HPV感染可能是导致本病中P53基因突变的直接原因。
P53 protein and human papillomavirus (HPV-Ag) were detected by immunohistochemistry in 11 cases of children with recurrent laryngeal papilloma. The results of p53 protein staining in all samples (11/11) were weak Positive, stained cells confined to basal epithelial cells, were scattered. HPV-Ag staining positive. The lung rate is 64% (7/11). Pointed that p53 gene mutations in this disease are frequent events may be related to the characteristics of this disease is easy to relapse. HPV infection may be the direct cause of P53 gene mutation in this disease.