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在２２例先天性心脏病患儿（ＣＨＤ）行右心导管检查中，通过检测应用维拉帕米（ＶＰ）前后的右室血浆心钠素（ＡＮＦ）浓度和血流动力学变化。结果显示：①应用ＶＰ前ＡＮＦ与平均肺动脉压（ｍＰＡＰ）明显正相关；②应用ＶＰ后伴肺动脉高压（ＰＡＨ）的ＣＨＤ患儿ＡＮＦ浓度与ｍＰＡＰ均明显降低；而肺动脉压正常患儿无明显变化。③ＶＰ对平均右房压，平均右室压和平均心率均无影响。本文提示钙拮抗剂——维拉帕米可降低ＣＨＤ伴ＰＡＨ患者的ｍＰＡＰ和右室ＡＮＦ水平。
Right ventricular catheterization was performed in 22 children with congenital heart disease (CHD) by measuring right ventricular plasma atrial natriuretic peptide (ANF) concentration and hemodynamic changes before and after application of verapamil (VP). The results showed that: (1) ANF was positively correlated with mean pulmonary arterial pressure (mPAP) before application of VP; (2) ANF concentration and mPAP were significantly decreased in CHD children with VP after pulmonary hypertension (PAH); while children with normal pulmonary hypertension did not . ③ VP on the average right atrial pressure, mean right ventricular pressure and average heart rate had no effect. This article suggests that the calcium antagonist verapamil may reduce mPAP and right ventricular ANF levels in CHD patients with PAH.