单纯疱疹病毒性脑炎患者脑脊液β_2微球蛋白含量的测定及临床意义

• 作 者: 赵钢 林国城 杨毅宁 粟秀初 戴文
• 机 构: 西安第四军医大学西京医院神经内科!710032,西安第四军医大学西京医院同位素科!710032,西安第四军医大学西京医院神经内科!710032,西安第四军医大学西京医院神经内科!710032,西安第四
• 出 处: 中国神经精神疾病杂志
• 发表日期: 1999年06期
• 关键词: 患者脑脊液 β_2微球蛋白 自身血清 淋巴细胞比例 白细胞计数 无显著性差异 动态检测 健康献血员 小淋巴细胞 试剂盒

目的　探讨单纯疱疹病毒性脑炎（ＨＳＥ） 患者脑脊液（ＣＳＦ） 和血清β２ 微球蛋白（β２ＭＧ） 的含量变化及其与ＣＳＦ 细胞数质量间的关系。方法　采用放射免疫法检测１５ 例ＨＳＥ患者和１６ 例正常人β２ＭＧ含量，并进行ＣＳＦ细胞学检查；对１０ 例ＨＳＥ患者ＣＳＦ进行动态观察。结果　①ＨＳＥ组ＣＳＦβ２ＭＧ 含量明显高于自身血清和ＣＳＦ对照组，ＨＳＥ组血清β２ＭＧ 含量与对照组无显著性差异。②ＨＳＥ组ＣＳＦ白细胞计数和激活淋巴细胞比例均高于对照组。③ＣＳＦＶβ２ＭＧ 含量随患者病情好转、白细胞计数和激活淋巴细胞比例的下降而降低。结论　ＨＳＥ 患者β２ＭＧ 含量的升高，主要是由激活淋巴细胞产生的。

Objective To investigate the changes of cerebrospinal fluid (CSF) and β2 microglobulin (β2MG) in patients with herpes simplex encephalitis (HSE) and its relationship with the number of CSF cells. Methods Radioimmunoassay was used to detect the content of β2MG in 15 cases of HSE and 16 cases of normal people. CSF cytology was performed. The CSF of 10 HSE patients was observed dynamically. Results ① HSE group CSFβ2 MG content was significantly higher than the serum and CSF control group, serum HSE group β2 MG content and the control group no significant difference. ② HSE group CSF white blood cell count and activated lymphocyte ratio were higher than the control group. ③ CSFVβ2 MG content with the patient’s condition improved, the white blood cell count and activated lymphocyte ratio decreased. Conclusions The increase of β2MG in HSE patients is mainly caused by activated lymphocytes.