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目的探讨M蛋白定量分析在多发性骨髓瘤(MM)的诊断和治疗中的应用。方法回顾性分析49例MM患者的临床资料与M蛋白之间的关系,并进行统计学分析。结果初治时IgG、IgA型及轻链型M蛋白的量与血红蛋白、血小板计数均呈负相关,M蛋白的量与初治时患者的骨质破坏程度无明显相关;肾功能不全的发生率IgG型低于IgA型及轻链型,三者之间相比差异有统计学意义(p<0.05);化疗2个疗程后M蛋白的下降与初治时M蛋白的量无明显相关。结论M蛋白是MM诊断和临床分期的重要指标,也是评价治疗是否有效的标准之一。
Objective To investigate the application of M protein quantitative analysis in the diagnosis and treatment of multiple myeloma (MM). Methods A retrospective analysis of 49 cases of MM patients with clinical data and M protein between the relationship and statistical analysis. Results The initial IgG, IgA and light chain M protein levels and hemoglobin, platelet count were negatively correlated, the amount of M protein and initial treatment of patients with no significant degree of bone destruction; the incidence of renal insufficiency IgG was lower than those of IgA and light chain, the difference was statistically significant (p <0.05). There was no significant correlation between the decrease of M protein and the amount of M protein during the initial course of chemotherapy. Conclusion M protein is an important indicator of the diagnosis and clinical stage of MM, and it is also one of the criteria for evaluating the effectiveness of treatment.