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1.1胰岛素/IGF-1的血液动力学效应 胰岛素和IGF-l对人和实验动物具有特有的生理学血管效应,引起骨骼肌血流(SMBF)增加和血管阻力下降.一些小组的研究表明,胰岛素呈剂量依赖性方式增加SMBF,其ED_(50)在消瘦的胰岛素敏感性人群中约为35μU/ml～40μU/ml.实验动物中胰岛素的效应因血管床的不同而有差异:在股、主动脉、冠脉及尾部血管显示舒血管作用,而在肠系膜动脉则具有缩血管效应.胰岛素对肾血管床亦有不同的作用,即舒张输出小动脉而使输入小动脉收缩,甚至亦有报道胰岛素的血管效应存在性别差异.IGF-1对血管张力的调节与胰岛素相似,其血管效应具有局部差异.但与胰岛素不同的是,IGF-1由心血管组织产生,并在那里产生自分泌/旁
1.1 Hemodynamic Effects of Insulin / IGF-1 Insulin and IGF-1 have unique physiological vascular effects on humans and laboratory animals that cause an increase in skeletal muscle blood flow (SMBF) and decreased vascular resistance Some studies have shown that insulin SMBF increased in a dose-dependent manner with an ED50 of about 35 uU / ml to 40 uU / ml in emaciated insulin-sensitive populations The effect of insulin in experimental animals varies between vascular beds: in the femoral and aortic , Coronary and caudal vessels showed vasodilator effects and vasoconstrictor effects in the mesenteric artery.Insulin also exerts a different effect on the renal vascular beds by contracting the arterioles and contracting the afferent arterioles and even reports that insulin There are gender differences in vascular effects.IGF-1 regulates vascular tone similar to insulin with local differences in vascular effects, but unlike insulin, IGF-1 is produced by cardiovascular tissue and produces autocrine / paravenous