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目的探讨绍兴地区妊娠早期妇女TORCH(Toxoplasma、Rubella Virus、Cytomegalovirus,CMV、HerpesimpiexVirus)的感染状况及其临床意义,为早期诊断和防治提供依据。方法采用抗体酶联免疫吸附试验法(ELISA法)检测11006例妊娠早期妇女血清中TORCH特异性抗体(IgM)阳性率。结果 HSV-IgM、CMV-IgM、TOX-IgM、RV-IgM的阳性感染率分别为1.42%、0.89%、0.50%、1.12%;两组妊娠结局:实验组自然流产、死胎、胎儿畸形、新生儿畸形等发生率明显高于对照组(P<0.005)。结论妊娠早期妇女TORCH检测可有效预防宫内感染及畸形胎儿出生,以提高优生优育质量。
Objective To investigate the infection status and clinical significance of TORCH (Toxoplasma, Rubella Virus, Cytomegalovirus, CMV, HerpesimpiexVirus) in early pregnancy in Shaoxing area and provide the basis for early diagnosis and prevention. Methods The positive rate of TORCH-specific antibody (IgM) in the serum of 1,006 pregnant women in early pregnancy was detected by enzyme-linked immunosorbent assay (ELISA). Results The positive rates of HSV-IgM, CMV-IgM, TOX-IgM and RV-IgM were 1.42%, 0.89%, 0.50% and 1.12% respectively. The pregnancy outcomes in both groups were spontaneous abortion, stillbirth, fetal malformation, Children deformity and other incidence was significantly higher than the control group (P <0.005). Conclusion The detection of TORCH in early pregnancy can effectively prevent intrauterine infection and birth of deformed fetus to improve the quality of prenatal and postnatal care.