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对28例精神分裂症住院病人进行氯氮平血药浓度测定,研究了药物代谢动力学、血药浓度与临床疗效及副作用的关系。发现血药浓度与疗效无显著相关,与副作用存在正相关。在相同剂量时血药浓度的个体差异较大,但大多数病人的血药浓度在200～700ng/ml范围内呈正态分布,多数病人的有效浓度>300ng/ml,血药浓度>600ng/ml时,疗效并不增加,而副作用则明显加重。本研究结果还提示,氯氨平剂量以300～400mg/d,血药浓度在200～600ng/ml为宜。
The concentration of clozapine in 28 inpatients with schizophrenia was measured, and the relationship between the pharmacokinetics and plasma concentration and clinical efficacy and side effects was studied. Blood concentration was found no significant correlation with the efficacy, there is a positive correlation with the side effects. In the same dose of plasma concentration of individual differences, but most patients with plasma concentrations in the range of 200 ~ 700ng / ml was normal distribution, the effective concentration of most patients> 300ng / ml, plasma concentration> 600ng / ml, the effect does not increase, while the side effects were significantly worse. The results also suggest that the dose of chloramine to 300 ~ 400mg / d, plasma concentration of 200 ~ 600ng / ml is appropriate.