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目的 :研究小剂量孕激素治疗未破裂卵泡黄素化综合征的临床疗效。方法 :选择2014年1月~2015年12月在我院进行诊治的未破裂卵泡黄素化综合征患者82例,随机分为观察组与对照组,每组各41例。观察组采用黄体酮和人绒毛膜促性腺激素治疗,对照组采用人绒毛膜促性腺激素治疗。B超监测排卵,观察患者受孕情况,检测雌二醇、孕酮和促黄体生成素水平,用彩色多普勒超声诊断仪检测卵泡发育侧卵巢动脉血流阻力指数。结果 :观察组的有效率为85.37%,明显高于对照组的63.41%;注射后30 h,观察组的孕酮水平明显升高,雌二醇和促黄体生成素无明显变化,对照组的雌二醇、孕酮和促黄体生成素均无明显变化;观察组的妊娠率为60.98%,排卵率为68.29%,均明显高于对照组;注射药物48h后,观察组的卵巢动脉血流阻力指数明显低于对照组。结论 :小剂量孕激素能提高未破裂卵泡黄素化综合征患者的妊娠率和排卵率,降低卵巢动脉血流阻力指数,具有重要的临床应用价值。
Objective: To study the clinical efficacy of low-dose progestin in treatment of luteinized unruptured follicle syndrome. Methods: A total of 82 patients with luteinized unruptured follicles who were diagnosed and treated in our hospital from January 2014 to December 2015 were randomly divided into observation group and control group, with 41 cases in each group. The observation group was treated with progesterone and human chorionic gonadotropin, while the control group was treated with human chorionic gonadotropin. B ultrasound monitoring ovulation, observe the patient’s pregnancy, estradiol, progesterone and luteinizing hormone levels were detected by color Doppler ultrasound diagnostic ovarian artery flow resistance index. Results: The effective rate of the observation group was 85.37%, which was significantly higher than that of the control group (63.41%). After 30 hours of injection, the progesterone level of the observation group was significantly increased, while the estradiol and luteinizing hormone did not change significantly. Diol, progesterone and luteinizing hormone had no significant changes in the observation group pregnancy rate was 60.98%, ovulation rate was 68.29%, were significantly higher than the control group; injection of drugs 48h after the observation group ovarian artery blood flow resistance The index was significantly lower than the control group. Conclusion: Low-dose progestin can increase the pregnancy rate and ovulation rate and reduce the index of ovarian artery blood flow resistance in patients with luteinized unruptured follicle syndrome, which has important clinical value.