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2型糖尿病(T2DM)导致的肝、肾损伤是糖尿病常见并发症,也是糖尿病死亡的主要原因之一~([1-2]),因此,预防及延缓T2DM并发症发生发展的研究及药物的开发备受人们关注。GK大鼠是自发性非肥胖型糖尿病动物模型~([3]),与人类T2DM病程特点尤为相似~([4])。本实验应用沙蓬粗寡糖(AOS)对GK大鼠进行干预,观察其对肝、肾的保护作用,为沙蓬进一步开发应用提供研究基础。
Liver and kidney injury caused by type 2 diabetes mellitus (T2DM) is a common complication of diabetes mellitus and one of the major causes of diabetes mellitus ([1-2]). Therefore, the study on preventing and delaying the development of T2DM complications and drugs Development of much attention. GK rats are spontaneous non-obese diabetic animal models ~ ([3]), and are particularly similar to human T2DM disease course (4). In this experiment, Ganshen rats were intervened by AOS to observe its protective effects on liver and kidney, which provided the basis for the further development and application of Sabouraya.