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目的:探讨缺血性脑血管病（ischemic cerebrovascular disorders,ICVD）病人血浆卵磷脂-胆固醇酰基转移酶（LCAT）活性与脂蛋白和红细胞膜脂质成分含量的相互关系。方法:采用改良的Nagaski酶学方法-外加底物法测定103例ICVD病人和60例健康者血浆LCAT活性,并检测血浆高密度脂蛋白胆固醇（HDL-C）及其亚组分（HDL2-C、HDL3-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1和B（apoA1,apoB）、红细胞膜胆固醇（RBCM-C）和红细胞膜磷脂（RBCM-PL）的含量变化。结果:ICVD病人血浆LCAT活性、HDL-C、HDL2-C及apoA1含量明显降低,血浆LDL-C、apoB、RBCM-C及RBCM-C/RBCM-PL比值显著增高,与对照组相比差异有显著性（P<0.05）,血浆LCAT活性分别与HDL-C、HDL2-C及apoA1水平呈正相关（P<0.05、P<0.05、P<0.05）,而与LDL-C（和RBCM-C呈负相关（P<0.05）。结论:ICVD病人脂质代谢异常与血浆LCAT活性降低有关。
Objective: To investigate the relationship between plasma lecithin - cholesterol acyltransferase (LCAT) activity and lipoprotein and erythrocyte membrane lipid components in patients with ischemic cerebrovascular disorders (ICVD). Methods: The plasma LCAT activity of 103 patients with ICVD and 60 healthy controls were detected by modified Nagaski enzymology method and substrate method. Plasma HDL-C and its sub-components (HDL2-C , HDL3-C, LDL-C, apoA1, apoB, RBCM-C and erythrocyte membrane phospholipid (RBCM-PL) Results: The plasma LCAT activity, HDL-C, HDL2-C and apoA1 levels in ICVD patients were significantly decreased, and the plasma LDL-C, apoB, RBCM-C and RBCM-C / RBCM-PL ratios were significantly increased (P <0.05). The plasma LCAT activity was positively correlated with HDL-C, HDL2-C and apoA1 levels (P <0.05, P <0.05, (P <0.05) .Conclusion: Abnormal lipid metabolism in patients with ICVD is associated with decreased plasma LCAT activity.