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根据中国、英国、德国和日本大量的周围T细胞淋巴瘤的组织学和免疫组化观察的结果,并与HTLV有关的病因及临床生物学行为相联系,提出T细胞淋巴瘤的工作分类。将周围T细胞淋巴瘤(PTL)分为低度和高度恶性二类。ATLL是由HTLV—1引起的,主要属于高度恶性类。某些肿瘤以混有其他细胞(表皮样细胞、滤泡的树突状细胞等)和结构(高内皮小静脉、滤泡)为特征,表明瘤细胞分泌淋巴因子。透明细胞对T细胞淋巴瘤似乎是特异的,可发生于不同类型的PTL内。
Based on the histological and immunohistochemical findings of a large number of peripheral T-cell lymphomas in China, the United Kingdom, Germany and Japan and in connection with the etiological and clinical biological behaviors associated with HTLV, a working classification of T-cell lymphoma was proposed. Peripheral T-cell lymphoma (PTL) is divided into two categories, low grade and high grade malignancy. ATLL is caused by HTLV-1, mainly belonging to the highly malignant category. Some tumors are characterized by the incorporation of other cells (epidermal-like cells, follicular dendritic cells, etc.) and structures (high endothelial venules, follicles), indicating that tumor cells secrete lymphokines. Clear cells appear to be specific to T-cell lymphomas and can occur within different types of PTL.