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目的 :孕激素治疗子宫内膜癌前病变 ,使其转变为正常内膜 ,测定治疗前后子宫内膜雌激素受体和孕激素受体 (ER.PR) ,以了解子宫内膜改变时 ,ER.PR的变化情况。方法 :对 32例癌前病变内膜孕激素治疗前后的石蜡切片 ,采用单克隆抗体免疫组化法测定子宫内膜 ER.PR。结果 :孕激素治疗后 ,子宫内膜由腺瘤样增生或非典型性增生逆转为正常内膜 ER.PR下降 ,前后有显著性差异 (P<0 .0 5 )。结论 :孕激素可有效的阻断子宫内膜癌前病变的恶变 ,并使其逆转为正常内膜 ,同时使子宫内膜 ER.PR下调。
Objective: Progesterone treatment of endometrial precancerous lesions, making it transformed into normal endometrium, determination of endometrial estrogen receptor and progesterone receptor (ER.PR) before and after treatment in order to understand the endometrial changes, ER .PR changes. Methods: The paraffin sections of 32 precancerous lesions of endometrial progesterone before and after treatment were determined by immunohistochemistry with monoclonal antibody ER.PR. Results: After progesterone treatment, ER.PR decreased from adenomatous hyperplasia or atypical hyperplasia to normal endometrium, there was a significant difference before and after (P <0.05). Conclusion: Progesterone can effectively block the malignant transformation of endometrial precancerous lesions and reverse it to normal endometrium, meanwhile, ER.PR can down-regulate the endometrium.