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复方甲硝唑漱口液是一种医院自制复方制剂,由甲硝唑、醋酸氯己定、薄荷脑、糖精钠、尼泊金组成,用于防止口腔感染,含量测定采用高效液相法,但由于医院目前没有高效液相色谱仪,因此含量测定实际不能进行。我们试验改用双波长分光光度法进行含量测定,发现尼泊金和糖精钠在220～400nm波长处有干扰,针对这种情况,我们对配方进行了改进,去掉配方中的尼泊金,并将糖精钠换成甜菊素,避免了含量测定的干扰。为
Compound metronidazole mouthwash is a hospital-made compound preparation, which consists of metronidazole, chlorhexidine acetate, menthol, sodium saccharin, and nipagin, which are used to prevent oral infections. The content of metronidazole is determined by HPLC method. However, due to the fact that there is no HPLC in the hospital at present, the determination of the content can not actually be carried out. We experimented with double-wavelength spectrophotometry to determine the content and found that the sodium and sodium saccharin in the 220 ~ 400nm wavelength interference, in view of this situation, we have improved the formula to remove the formulation of the paraben and The sodium saccharin replaced by stevia, to avoid the interference of determination. for