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1902年Michaelis和Gutmann对两名长期患膀胱炎的女尸解剖时发现一些奇特的病变。一年后Von Hansemann起名为软斑症,并作了细致的组织学检查,强调一个重要特征:变形的巨噬细胞,后被命名为Von Hansemann细胞。此后,发表的一些文章描写疾病主要侵犯泌尿系统,至1958年后才开始报道泌尿系以外的软斑症。目前,世界上已发表了200多例,女性占4/5。最初,软斑症被看作是癌肿,接着被认为类拟于结核,肉样瘤一类疾病。至今,除了病理变化仍含糊不清外,认为大肠杆菌是起了主要作用。最近,由于在Von Hansemann细胞的呈现和Michaelis-Gutmann体的形成上获得成功,软斑症属于巨噬细胞类疾病,如同Whipple病和Chediak-Higashi病,以及黄色肉芽肿性肾盂肾炎和肉芽肿性睾丸炎等
In 1902, Michaelis and Gutmann found some strange lesions in the dissection of two women who had long-term cystitis. A year later Von Hansemann named soft plaque and made a careful histological examination, highlighting an important feature: the deformed macrophages, which were later named Von Hansemann cells. Since then, published articles describing diseases predominantly affecting the urinary system did not begin to report soft plaque other than the urinary tract after 1958. At present, more than 200 cases have been published in the world, and women account for 4/5. Initially, soft plaque was seen as a cancer, which was then considered a type of disease in tuberculosis and sarcoidosis. So far, in addition to the pathological changes are still vague, that E. coli played a major role. Recently, due to success in the presentation of Von Hansemann’s cells and the formation of the Michaelis-Gutmann body, soft spots belong to macrophage-like diseases, like Whipple’s disease and Chediak-Higashi disease, as well as yellow granulomatous pyelonephritis and granulomatous Orchitis and so on