Synthesis, Crystal Structure and DNA Binding Studies of a Nickel(II) Complex with 2-Aminomethylbenzi

• 作 者: 李士坤 林秋月 吕天喜 王彦君 陈东
• 机 构: Zhejiang Key Laboratory for Reaction Chemistry on Solid Surfaces, Zhejiang Normal University,College
• 出 处: 结构化学
• 发表日期: 2010年11期
• 关键词: viscosity DNA monoclinic constants nickel carboxylate intercalation coordinated

A new mixed-ligand nickel(Ⅱ) complex, [Ni(L)(DCA)(H2O)]·2H2O (L = C8H9N3, 2-aminomethyl-benzimidazole, DCA2- = 7-oxabicyclo[2,2,1]heptane-2,3-dicarboxylate, demethylcantharate, C8H8O5), has been synthesized and characterized. The structure of the complex was determined by single-crystal X-ray diffraction. It is of monoclinic system, space group P21/c with a = 7.7211(7), b = 12.0799(12), c = 19.7867(19), β = 100.390(6)°, V = 1815.2(3) nm3, Dc = 1.625 g·cm-3, Ζ = 4, F(000) = 928, R = 0.0314 and wR = 0.0822. In addition, the interaction between the complex and DNA was studied by means of fluorescence spectra and viscosity. The results indicate that the complex binds to DNA by the mode of partial intercalation with the Stern-Volmer constants Ksv of 3.81 × 104 mol·L-1.

A New mixed-ligand nickel (II) complex, [Ni (L) (DCA) (H2O)] 2H2O (L = C8H9N3, 2-aminomethyl- benzimidazole, DCA2- = 7- oxabicyclo [2,2,1] heptane -2,3-dicarboxylate, demethylcantharate, C8H8O5), has been synthesized and characterized. The structure of the complex was determined by single-crystal X-ray diffraction. It is of monoclinic system, space group P21 / c with a = 7.7211 Β = 100.390 (6) °, V = 1815.2 (3) nm3, Dc = 1.625 g · cm-3, Ζ = 4, F ) = 928, R = 0.0314 and wR = 0.0822. In addition, the interaction between the complex and DNA was studied by means of fluorescence spectra and viscosity. The results that that the complex binds to DNA by the mode of partial intercalation with the Stern -Volmer constants Ksv of 3.81 × 104 mol·L-1.