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目的探讨血清透明质酸(HA)和Ⅲ型前胶原氨基端肽(PCⅢNP)预测早产儿支气管肺发育不良(BPD)的价值。方法选择2006年1月至2010年9月在我科住院、胎龄<32周或体重<1500g的早产儿,分别检测生后第1、14、28、42天血清HA和PCⅢNP水平,其中诊断BPD的早产儿为BPD组,从未合并BPD的早产儿中随机选取30例与BPD组胎龄、体重、性别相匹配的早产儿为对照组。比较两组HA和PCⅢNP的动态变化。结果 BPD组出生第1天血清HA和PCⅢNP水平与对照组差异无统计学意义[(86.3±5.2)μg/L比(90.6±6.6)μg/L,(8.1±1.3)μg/L比(7.6±2.1)μg/L,P均>0.05],生后第14、28、42天明显高于对照组[HA:(185.3±8.2)μg/L比(95.0±6.3)μg/L,(251.7±6.4)μg/L比(98.3±5.3)μg/L,(168.8±5.5)μg/L比(96.4±4.7)μg/L;PCⅢNP:(30.6±3.2)μg/L比(10.1±1.1)μg/L,(65.6±4.5)μg/L比(10.3±3.0)μg/L,(25.6±2.2)μg/L比(10.6±2.2)μg/L,P均<0.05];BPD组血清HA和PCⅢNP水平在28天内呈进行性上升,28天后逐渐下降。结论血清HA和PCⅢNP水平有助于早产儿BPD的早期预测。
Objective To investigate the value of serum hyaluronic acid (HA) and type Ⅲ procollagen amino terminal peptide (PCⅢNP) in predicting bronchopulmonary dysplasia (BPD) in preterm infants. Methods From January 2006 to September 2010 in our department, hospitalized, gestational age <32 weeks or weight <1500g of premature children were detected on the 1st, 14th, 28th and 42nd postnatal serum HA and PCⅢNP levels, of which diagnosis The premature infants of BPD group were BPD group. 30 preterm infants born without BPD were randomly selected from 30 preterm infants with gestational age, weight and gender matched in BPD group as the control group. The dynamic changes of HA and PCⅢNP in two groups were compared. Results There was no significant difference in serum HA and PCⅢNP levels between the first day of birth and the control group [(86.3 ± 5.2) μg / L vs (90.6 ± 6.6) μg / L, (8.1 ± 1.3) μg / L vs ± 2.1) μg / L, all P> 0.05]. The levels of serum lipids in the control group were significantly higher than those of the control group on the 14th, 28th and 42nd days after birth [HA: (185.3 ± 8.2) μg / L (P <0.01), and the ratio of PCⅢNP (30.6 ± 3.2) μg / L was (10.1 ± 1.1) ± (6.4 ± 0.4) μg / L and (98.8 ± 5.3) μg / L, (65.6 ± 4.5) μg / L vs (10.3 ± 3.0) μg / L, (25.6 ± 2.2) μg / L vs PCⅢNP levels increased progressively within 28 days, and gradually decreased 28 days later. Conclusion Serum HA and PCⅢNP levels are helpful for the early prediction of BPD in preterm infants.