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目的:观察凉血解毒口服液抗菌抗病毒作用。方法:采用试管稀释法测定凉血解毒口服液体外最小抑菌浓度。以小鼠流感病毒肺炎为动物模型,计算肺指数及肺指数抑制率,并研究其对感染小鼠的死亡保护作用。结果:凉血解毒口服液对伤寒杆菌、大肠杆菌、痢疾杆菌、金黄色葡萄球菌、肺炎克雷伯氏菌具有较好的抑制作用;口服给予140~280 mg/kg剂量,可明显降低感染小鼠的肺指数,延长小鼠的存活时间。结论:凉血解毒口服液具有抗菌及抗流感病毒作用。
Objective: To observe the antibacterial and antiviral effects of Liangxuejiedu oral liquid. Methods: The tube broth dilution method was used to determine the minimum inhibitory concentration of Liangxue Jiedu oral liquid. Mouse influenza virus pneumonia was used as an animal model to calculate the lung index and lung index inhibition rate, and to study the protective effect of death on infected mice. Results: Liangxue Jiedu Oral Liquid had a good inhibitory effect on Salmonella typhi, Escherichia coli, Shigella, Staphylococcus aureus, and Klebsiella pneumoniae; oral dose of 140-280 mg/kg could significantly reduce the infection. The mouse’s lung index prolongs the survival of mice. Conclusion: Liangxue Jiedu Oral Liquid has antibacterial and anti-influenza virus effects.