Differential regulation of protein synthesis in skeletal muscle and liver of neonatal pigs by leucin

• 作 者: Agus Suryawan Hanh V Nguyen Ro
• 机 构: DepartmentofPediatrics
• 出 处: 畜牧与生物技术杂志：英文版
• 发表日期: 2012年1期
• 关键词: 高蛋白质 亮氨酸 合成率 猪肝脏 骨骼肌 新生儿 蛋白激酶B 雷帕霉素 leucine mTORC1 neonatal pigs rapamycin s
• 基金项目: Acknowledgements We thank Jerome Stubblefield for the care of animals and Linda Kemper for secretarial assistance. Supported by NIH R01 AR44474 and USDA 58-6250 6-001. This work is a publication of th

Neonatal growth is characterized by a high protein synthesis rate that is largely due to an enhanced sensitivity to the postprandial rise in insulin and amino acids, especially leucine. The mechanism of leucine’s action in vivo is not well understood. In