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目的:观察纳洛酮对血管迷走性晕厥(VVS)的治疗效果,寻找治疗VVS的新途径。方法选择两组病人进行病例对照观察。对照组:38例VVS患者常规使用丹参注射液、能量和剂治疗;治疗组:40例VVS患者在常规治疗的基础上静脉注射纳洛酮注射液0.4～0.8mg,于注射后每30、60、120min监测血压、心率、心电图,观察临床症状和体征,与对照组比较。判定标准:30mnin内临床症状缓解,血压、心率、心电图恢复正常为显效;30～60min内达到以上标准为有效;60min或以上未达到以上标准或部分未达到标准为无效。统计学处理:观察资料用SPSS5.0forwindows统计软件包处理,进行t检验、方差分析,P<0.05为显著性差异,P<0.01为非常显著性差异。结果治疗组疗效明显优于对照组(P<0.01)。治疗组总有效率为95%,对照组总有效率为63.2%。两组都能升高患者收缩压和心率在正常范围内,但治疗组升高血压和心率较对照组更快。结论那洛酮用于治疗血管迷走性晕厥安全、起效快,可作为血管迷走性晕厥的另一治疗药物。
Objective: To observe the therapeutic effect of naloxone on vasovagal syncope (VVS) and to find a new way to treat VVS. Methods Two groups of patients were selected for case control study. In the control group, 38 patients with VVS were treated with Salvia miltiorrhiza injection, energy and agent routinely. In the treatment group, 40 patients with VVS received intravenous injection of naloxone injection 0.4 ~ 0.8mg on routine therapy, , 120min blood pressure, heart rate, ECG, clinical symptoms and signs were observed, compared with the control group. Criteria: 30mnin clinical symptoms, blood pressure, heart rate, electrocardiogram returned to normal as marked; 30 ~ 60min to achieve the above criteria are valid; 60min or above did not meet the above criteria or some did not meet the standard is invalid. Statistical analysis: The observation data were processed with SPSS5.0forwindows statistical software package, t test and analysis of variance, P <0.05 was significant difference, P <0.01 was very significant difference. Results The treatment group was significantly better than the control group (P <0.01). The total effective rate was 95% in the treatment group and 63.2% in the control group. Systolic blood pressure and heart rate were elevated in both groups within the normal range, but the treatment group had higher blood pressure and heart rate than the control group. Conclusion Naloxone is safe and effective for vasovagal syncope and can be used as another therapeutic for vasovagal syncope.