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Flexible pipelines are often used to connect hard pipes from a foundation to a superstructure to accommodate large deformation in the base isolation layer during an earthquake.Although Chinese seismic design guidelines suggest several configurations,they are different from the designs that have been proven in practice,e.g.,Japanese styles,and extensive experimental investigation into their seismic performance is required.Three types of seals,rubber-,metal-and asbestine-based,were tested quasi-statically with infilled pressurized water at 2.5 MPa.The asbestine-based seal leaked at a smaller deformation than the other two types of seals.Based on the test results,three damage states were defined and the deformation capacity was estimated.To evaluate their performance,a three-dimensional model of a base-isolated medical building was developed using OpenSees,with the flexible pipelines simulated by a mechanical model calibrated from the experimental data.A probabilistic seismic demand model and the fragility function of the flexible pipelines were then developed to evaluate the seismic performance.