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目的探讨口服胺碘酮对病态窦房结综合征(病窦综合征)合并阵发性心房扑动或心房颤动并植入心脏起搏器患者的起搏阈值的影响,为植入心脏起搏器后,因快速性房性心律失常口服胺碘酮是否安全提供依据。方法监测15例因病态窦房结综合征(病窦综合征)合并阵发性心房扑动或心房颤动植入心脏起搏器并同时口服胺碘酮患者的术中、术后1月、术后3月、术后6月起搏阈值,同时监测同时间段15例因单纯病态窦房结综合征植入心脏起搏器患者的起搏阈值,并进行统计学分析。结果胺碘酮治疗组与对照组术中阈值无明显差别(P>0.05)。胺碘酮治疗组术后1月内起搏阈值明显增高,与术中相比有显著性差异(P<0.05),术后3月与术后1月相比,起搏阈值明显降低,有显著性差异(P<0.05),术后6月于3月相比,起搏阈值虽有降低趋势,但无显著性差异(P>0.05)。对照组术后1月内起搏阈值明显增高,与术中相比有显著性差异(P<0.05),术后3月内起搏阈值亦明显降低,与术后1月相比有显著性差异(P<0.05),术后6月于3月相比,起搏阈值无显著性差异(P>0.05)。治疗组与对照组术中、术后1月、术后3月、术后6月相比起搏阈值均无显著性差异。结论胺碘酮对心室起搏阈值无显著性影响。
Objective To investigate the effect of oral amiodarone on the pacing threshold in patients with sick sinus syndrome (sick sinus syndrome) complicated with paroxysmal atrial flutter or atrial fibrillation and implanted pacemakers, After the device, due to rapid atrial arrhythmia oral amiodarone is safe to provide the basis. Methods Fifteen patients with sick sinus syndrome (sick sinus syndrome) with paroxysmal atrial flutter or atrial fibrillation were implanted with pacemakers and patients with amiodarone were enrolled in this study. After 3 months, 6 months after pacing threshold, while at the same time monitoring 15 cases of simple sick sinus syndrome implanted pacemakers in patients with pacing threshold, and statistical analysis. Results Amiodarone treatment group and control group intraoperative threshold no significant difference (P> 0.05). In the amiodarone group, the pacing threshold was significantly increased within 1 month after operation, which was significantly different from that in the operation group (P <0.05). The pacing threshold was significantly lower in the amiodarone group than in the postoperative one month There was no significant difference (P> 0.05) between the pacing threshold and the pacing threshold. In the control group, the pacing threshold was significantly increased within 1 month after operation, which was significantly different from that during operation (P <0.05). The pacing threshold was also significantly decreased within 3 months after operation, which was significantly lower than that at 1 month after operation (P <0.05). There was no significant difference in pacing threshold between June and March (P> 0.05). There was no significant difference in pacing threshold between the treatment group and the control group during operation, 1 month after operation, 3 months after operation and 6 months after operation. Conclusions Amiodarone has no significant effect on ventricular pacing threshold.