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目的：研究并分析治疗恶性梗阻性黄疸患者时使用125I粒子条联合胆道支架植入的效果。方法整群收集2013年1月—2015年9月在该院进行治疗的恶性梗阻性黄疸患者共80例,根据平行、单盲、随机对照的设计原则分为对照组(40例)和观察组(40例),对照组患者接受胆道支架植入治疗,而观察组在此基础上联合使用125I粒子条植入治疗。结果观察组术后1、3个月的肿瘤标志物CA199水平为(64.3±20.5)、(77.8±19.9)U/mL,显著低于对照组的(269.6±218.9)、(349.3±189.6)U/mL。结论在恶性梗阻性黄疸患者的治疗过程中,125I粒子条联合胆道支架植入能够显著抑制肿瘤生长,值得推广应用。“,”Objective To study and analyze the treatment of malignant obstructive jaundice patients with 125 I particles as-sociated biliary stenting. Methods Group to collect 2013 January to September 2015 in our hospital for therapy of malignant obstructive jaundice patients with a total of 80 cases, according to the parallel, single blind, randomized controlled design principle divided into the control group (40 cases) and observation group (40 cases), biliary stent implantation in the treat-ment of patients in the control group received, and the observation group based on the combined use of 125I seed implants treatment. Results In the observation group after 1 month, 3 months of tumor markers CA199 levels (64.3 ±20.5) U/mL(77.8 ±19.9) U/mL, significantly lower than the control group(269.6 ± 218.9) U/mL,(34.93 ± 18.96) U/mL. Conclusion In the pro-cess of the treatment of patients with malignant obstructive jaundice, 125 I particles associated biliary stenting can signifi-cantly inhibit tumor growth, is worthy of popularization and application.