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目的探讨大肠癌组织MMP-3表达及其临床意义。方法用免疫组化SP法测定66例大肠癌组织及癌旁正常组织MMP-3表达,分析MMP-3表达与大肠癌临床病理因素之间的关系。结果癌组织和癌旁正常组织MMP-3表达有显著性差异(P<0.05)。癌组织MMP-3表达与淋巴结转移、血管侵犯、肝转移及肿瘤病理分期密切相关(P<0.05),与肿瘤部位、肿瘤大小、组织学类型及患者的性别和年龄等无关(P>0.05)。结论MMP-3表达同大肠癌生物学行为密切相关,可能与大肠癌的发生、发展及预后有关联。
Objective To investigate the expression of MMP-3 in colorectal cancer and its clinical significance. Methods The expression of MMP-3 in 66 cases of colorectal cancer tissues and adjacent normal tissues was detected by immunohistochemical SP method. The relationship between the expression of MMP-3 and clinicopathological parameters of colorectal cancer was analyzed. Results There was a significant difference in the expression of MMP-3 between cancer tissues and adjacent normal tissues (P <0.05). The expression of MMP-3 in cancerous tissues was closely related to the lymph node metastasis, vascular invasion, liver metastasis and tumor pathological stage (P <0.05), but not to the tumor location, tumor size, histological type and patient’s gender and age (P> 0.05) . Conclusion The expression of MMP-3 is closely related to the biological behavior of colorectal cancer and may be related to the occurrence, development and prognosis of colorectal cancer.