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目的在超微结构水平阐明内分泌因素对骨缺损修复的影响。方法采用狗牙槽骨二壁骨缺损模型，观察在切除卵巢，诱发糖尿病及提高甲状腺素水平情况下牙槽骨修复过程中的超微结构变化。结果去除卵巢组新骨形成明显较同期正常对照组慢；诱发糖尿病组骨质明显稀疏，可见胶原破坏和退变细胞；甲状腺素组可见骨质形成减少，6个月时尤为明显，大部分骨缺损部位被纤维缔组织所代替。结论证实牙槽骨修复确受全身内分泌因素调控。
Objective To clarify the effect of endocrine factors on the repair of bone defects at the ultrastructure level. Methods The model of two-wall bone defect in dog's alveolar bone was used to observe the ultrastructural changes of alveolar bone in the process of alveolar bone removal after ovariectomy, diabetes mellitus and elevated thyroxine level. Results The formation of new bone in the ovariectomized group was significantly slower than that in the normal control group at the same period. The bone in the induced diabetic group was obviously sparse and the collagen was destroyed and degenerated. The bone formation decreased in the thyroid hormone group, especially at 6 months. The defect is replaced by fibrous connective tissue. Conclusions confirmed that alveolar bone repair by systemic endocrine factors.