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从近代免疫观点看来,妊娠可以说是同种异体移植,而妊娠之所以能继续,则有赖于母一婴之间一系列防排斥机制所确立的免疫平衡。一旦平衡失调,可能导致病理情况。有证据表明妊娠高血压综合征可能与母体胚胎抗原负载过大和保护性抗体(系IgG)产生不足有关。伴有尿蛋白的妊娠高血压综合征患者,在肾脏和子宫螺旋小动脉之血管内皮或基底膜上,可见 IgG、IgM 和 C_3之沉着。胎儿可以逃脱免疫的损伤,一方面由于胎盘之屏障可使进入胎体内的母体 T 细胞停止分裂,丧失其攻击能力,另一方面由于胎儿本身产生一些免疫抑制因子,其中较为重要的是甲胎蛋白(AFP)而
From the point of view of modern immunization, pregnancy can be described as allograft, and the reason why pregnancy can continue depends on the immune balance established by a series of anti-rejection mechanisms between mother and baby. Once the imbalance, may lead to pathological conditions. There is evidence that pregnancy-induced hypertension syndrome may be related to over-loading of maternal embryonic antigens and insufficient production of protective antibodies (tethered IgG). Patients with gestational hypertension associated with urinary protein showed signs of IgG, IgM, and C_3 sedation on the vascular endothelium or basement membrane of the renal and uterine spiral arterioles. Fetuses can escape immune damage, on the one hand due to the placental barrier can cause maternal T cells into the carcass to stop dividing, loss of its ability to attack, on the other hand due to the fetus itself produces some immunosuppressive factors, of which more important is the fetoprotein (AFP)