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目的;探讨氟马西尼在逆转急性苯二氮(艹卓)药物(BZDs)中毒所致意识障碍方面的效果。方法:采用随机方法将126例患者分为氟马西尼治疗组和常规治疗组,每组均为63例。疗效分析采用修改的Glasgow昏迷量表(MGCS)和观察者对患者的机敏力/镇静程度评判量表(OAA/S)。结果:两组患者治疗后MGCS得分均较治疗前增加,但氟马西尼组增加更明显,两组比较差异有显著性(P<0.01)。结论:氟马西尼治疗对急性BZDs中毒确有不同程度的症状逆转作用,且没有严重的副反应。
Objectives; To investigate the effect of flumazenil in reversing the disturbance of consciousness caused by acute benzodiazepines (BZDs) poisoning. Methods: 126 patients were randomly divided into flumazenil treatment group and conventional treatment group, each group was 63 cases. Efficacy analyzes were based on modified Glasgow coma scale (MGCS) and observer sensitivity / sedation scores (OAA / S) for patients. Results: The scores of MGCS increased after treatment in both groups, but the increase in flumazenil group was more obvious. There was significant difference between the two groups (P <0.01). Conclusion: Flumazenil treatment has definite degree of reversal of symptoms in acute BZDs poisoning without serious side effects.