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内毒素 (LPS)是革兰氏阴性细菌致病的主要因素 ,它引起机体的一系列炎症反应。LPS是怎样引起炎症反应的呢 ?研究发现 :LPS与Toll样受体家族有关。本文概述了Toll样受体家族的分子生化及有关配体、信号传递通路等内容。研究表明 :Toll样受体在将LPS刺激信号向细胞内传递及在调节炎症因子的级联反应中起着重要作用
Endotoxin (LPS) is a major cause of gram-negative bacterial pathogenesis, which causes a series of inflammatory reactions in the body. LPS is how to cause inflammation? Study found: LPS and Toll-like receptor family. This article summarizes the molecular biochemistry and related ligands and signaling pathways of the Toll-like receptor family. Studies have shown that Toll-like receptors play an important role in transmitting LPS stimulatory signals to cells and in the cascade of inflammatory cytokines