P-Dodecylbenzenesulfonic acid(DBSA),a Brфnsted acid-surfactant catalyst for Biginelli reaction in wa

• 作 者: Mohammad Ali Bigdeli Ghazaleh Gholami Enayatollah Sheikhhosseini
• 机 构: Faculty of Chemistry,Tarbiat Moallem University,49 Mofateh,Tehran,Iran,
• 出 处: Chinese Chemical Letters
• 发表日期: 2011年08期
• 关键词: surfactant considerably herein afford comparable shorter covalently moiety aldeh

We report herein the use of p-dodecylbenzenesulfonic acid(DBSA) as a catalyst for a one-pot Biginelli reaction to afford 3,4- dihydropyrimidinone derivatives in good to excellent yields.This reaction proceeds efficiently in water and under solvent free conditions.Comparisons of results indicate that although the yields are high and comparable for both methods,the reaction times are considerably shorter under solvent free conditions.

We report herein the use of p-dodecylbenzenesulfonic acid (DBSA) as a catalyst for a one-pot Biginelli reaction to afford 3,4- dihydropyrimidinone derivatives in good to excellent yields. This rapid prior to running in and solvent free conditions. Comparisons of results that that the the yield are high and comparable for both methods, the reaction times are preferably shorter under solvent free conditions.