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美国旧金山消息:关于胆固醇的主要蛋白载体的遗传密码已经被破译。此发现有希望很快用一种简单的试验早期识别具有早发性心脏病遗传倾向的人. 新近发表了低密度脂蛋白(LDL)脱辅基脂蛋白B(apo-B)的正常形态详细基因序列,从而世界许多研究人员正在寻找此蛋白的变异体并试图探讨哪些基因突变与早发性心脏病有联系。此项研究已在几个中心开展,并已鉴定出apo-B的几种变异,加利福尼亚旧金山大学Glad Stone基金会实验室的Brian Mc Carthy说:“需要收集许多份正常人及具有高胆固醇血症或有早发性心脏病家族倾向的人的标本。”
SAN FRANCISCO, USA: The genetic code for the major protein carrier of cholesterol has been deciphered. This finding promises to quickly identify individuals with a genetic predisposition to early-onset heart disease in a simple trial soon.Normally, the details of the normal morphology of low-density lipoprotein (LDL) apolipoprotein B (apo-B) Gene sequence, so many researchers around the world are looking for variants of this protein and trying to find out which gene mutations are associated with early-onset heart disease. This research has been conducted in several centers and several variants of apo-B have been identified, said Brian Mc Carthy of the Glad Stone Foundation Laboratory, University of San Francisco, California, “Many patients need to be collected and have hypercholesterolemia Or a specimen of a person with a family history of early-onset heart disease. ”