尼可地尔同源物对离体人子宫肌层的影响

• 作 者: Parimala K. Peedicayil J. Peedicayil A. 张新艳
• 机 构: Department of Obstetrics and Gynaecology Christian Medical College,Vellore,632004,India,
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2006年12期
• 关键词: 尼可地尔 子宫肌层 同源物 非妊娠期 子宫切除手术 非参数检验 浓度 研究设计 肌束 曲线

Objective:To determine the effect of a nicorandil congener,SG-209 on the myometrium. Study design:Isolated strips of myometrium,from nine women who underwent hysterectomy,were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5,3.0 and 10 μM). The mean height of contraction and the area under the curve were analysed using a non-parametric test. Results:At a 10 μMconcentration,SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p < 0.05). Conclusion:SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener,nicorandil,it may be useful in clinical conditions that require uterine relaxation.

Objective: To determine the effect of a nicorandil congener, SG-209 on the myometrium. Study design: Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG -209 (1.5, 3.0 and 10 μM). The mean height of contraction and the area under the curve were analyzed using a non-parametric test. Results: At a 10 μM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p <0.05). Conclusion: SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.