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目的观察米索前列醇用于预防剖宫产术后出血的临床效果。方法选择240例剖宫产患者,随机分为观察组及对照组。观察组120例,胎儿娩出后宫体注射缩宫素20 u、静脉滴注缩宫素20u,同时予米索前列醇400 ug用生理盐水润湿后置于直肠内。对照组120例,胎儿娩出后宫体注射缩宫素20 u、静脉滴注缩宫素20 u。观察两组患者术中及术后24 h内的产后出血量、产后出血发生率以及用药前后生命征变化及副反应的情况。结果观察组术后24 h平均出血量(265±54)ml,与对照组(368±58)ml比较,差异有统计学意义(P<0.05)。两组患者术中出血量及用药前后生命征变化比较,差异无统计学意义(P>0.05)。结论在常规使用缩宫素的同时,采用术中予米索前列醇塞直肠,能减少剖宫产术后出血。是一种简单、安全、有效的预防产后出血的方法。
Objective To observe the clinical effect of misoprostol in preventing bleeding after cesarean section. Methods 240 cases of cesarean section were randomly divided into observation group and control group. Observation group of 120 cases, the fetus was delivered to the uterus after injection of oxytocin 20 u, intravenous infusion of oxytocin 20u, while misoprostol 400 ug wet with saline placed in the rectum. Control group of 120 cases, the fetus was delivered after injection of oxytocin 20 u, intravenous oxytocin 20 u. The incidence of postpartum hemorrhage, the incidence of postpartum hemorrhage, and the changes of the vital signs before and after treatment and the side effects were observed during and within 24 hours after operation. Results The mean amount of bleeding at 24 hours after operation in the observation group was (265 ± 54) ml, which was significantly lower than that in the control group (368 ± 58) ml (P <0.05). There was no significant difference between the two groups in the amount of bleeding and the change of vital signs before and after treatment (P> 0.05). Conclusion Oxytocin in the routine use of the same time, intraoperative preoperative misoprostol plug rectum, can reduce bleeding after cesarean section. Is a simple, safe and effective way to prevent postpartum hemorrhage.