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目的：定量研究增殖性玻璃体视网膜病变（ＰＶＲ）患者玻璃体中碱性成纤维细胞生长因子（ｂＦＧＦ）的含量，阐明ｂＦＧＦ在ＰＶＲ中的作用和影响。方法：双夹心酶联免疫吸附技术测定正常对照组２０只眼、ＰＶＲＣ组３５只眼、ＰＶＲＤ组２６只眼和单纯玻璃体出血组２５只眼患者玻璃体内ｂＦＧＦ含量，以及ＰＶＲＤ病人（１５例）血清内ｂＦＧＦ含量。结果：①玻璃体内ｂＦＧＦ含量：对照组ｍｅｄｉａｎ５．２０ｎｇ／Ｌ，ｑｕａｒｔｉｌｅ１５．４７ｎｇ／Ｌ；ＰＶＲＣ组ｍｅｄｉａｎ３．１２ｎｇ／Ｌ，ｑｕａｒｔｉｌｅ１０．４８ｎｇ／Ｌ；ＰＶＲＤ组ｍｅｄｉａｎ４６．５６ｎｇ／Ｌ，ｑｕａｒｔｉｌｅ１１３．９６ｎｇ／Ｌ；单纯玻璃体出血组ｍｅｄｉａｎ１．４０ｎｇ／Ｌ，ｑｕａｒｔｉｌｅ６．２５ｎｇ／Ｌ；ＰＶＲＤ组玻璃体内ｂＦＧＦ含量明显高于对照组，也高于ＰＶＲＣ组和单纯玻璃体出血组（各Ｐ＜０．０１）；②ＰＶＲＤ组血清内ｂＦＧＦ含量：（１８．３３±３．３９）ｎｇ／Ｌ；ＰＶＲＤ组玻璃体内ｂＦＧＦ含量明显高于其血清含量，Ｐ＜０．０１；③玻璃体内ｂＦＧＦ含量与裂孔面积的关系：在ＰＶＲＤ组，裂孔大于１５ｍｍ×１５ｍｍ组ｂＦＧＦ含量较高（Ｐ＜０?
OBJECTIVE: To quantitatively study the content of bFGF in vitreous of patients with proliferative vitreoretinopathy (PVR) and to elucidate the role and influence of bFGF in PVR. Methods: Double-sandwich enzyme-linked immunosorbent assay was used to determine the intravitreal bFGF content in 20 eyes of normal control group, 35 eyes of PVR-C group, 26 eyes of PVR-D group and 25 eyes of simple vitreous hemorrhage group, Serum bFGF content in patients (15 cases). Results: ① bFGF content in vitreous: control group median5.20ng / L, quartile15.47ng / L; PVR-C group median3.12ng / L, quartile10.48ng / L; PVR-D group median46.56ng / L, quartile113. 96ng / L; simple vitreous hemorrhage median1.40ng / L, quartile6.25ng / L; PVR D group vitreous bFGF content was significantly higher than the PVR C group and simple vitreous hemorrhage group (P < 0.01). ②The content of bFGF in PVRD group was (18.33 ± 3.39) ng / L, the content of bFGF in PVRD group was significantly higher than that of PVRD group Within bFGF content and the relationship between the area of the hiatus: PVR D group, the hole is greater than 1 5mm × 1 5mm group bFGF higher (P <0?