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目的 探讨高血压患者的认知状态及其与血压的关系。方法 对 95例高血压患者及正常对照组进行基本认知和脑MRI检查。结果 高血压组认知测验TS(63 .5± 13 .9)显著低于对照组 (67.6± 11.6) ;DDRT明显延长、DWM广度明显减小、DWR成绩显著降低。脑MRI正常的高血压者TS(62 .0± 14 .6)也显著低于对照组(67.0± 10 .9)。多因素分析显示收缩压升高是TS、DDRT、DWM广度、DWR成绩的独立危险因素 ;舒张压升高是DWM广度、DWR成绩的独立危险因素。结论 高血压患者的认知损害可能发生在脑MRI异常之前 ;血压水平与认知功能之间呈一定的量效关系
Objective To investigate the cognitive status of patients with hypertension and its relationship with blood pressure. Methods 95 patients with hypertension and normal control group for basic cognitive and brain MRI examination. Results Compared with control group, the TS (63.5 ± 13.9) in hypertension group was significantly lower than that in control group (67.6 ± 11.6). The DDRT was significantly prolonged and the DWM width was significantly reduced. The DWR score was significantly lower. The TS of hypertensive patients with normal brain MRI (62.0 ± 14.6) was also significantly lower than that of the control group (67.0 ± 10.9). Multivariate analysis showed that elevated systolic blood pressure was an independent risk factor of TS, DDRT, DWM breadth and DWR scores; diastolic blood pressure was an independent risk factor of DWM breadth and DWR score. Conclusions Cognitive impairment in hypertensive patients may precede abnormal MRI of the brain. There is a certain dose-effect relationship between the blood pressure level and cognitive function