Regulation of Zishen Qinggan( Shuangyi) Prescription to Insulin Resistance of GK Rats

• 作 者: Chunyu TIAN Chen XING Haimei BO Liang ZHU Xiaojin LA Huijuan CAO Xin YAN Yuyang YANG Xuemei ZHOU Ji\'an LI Yongsen JIA
• 机 构: North China University of Science and Technology,
• 出 处: Medicinal Plant
• 发表日期: 2017年03期
• 关键词: glucosidase dosage fasting administration glucagon hemoglobin Insulin secretion

[Objective] To study the effects of Zishen Qinggan( Shuangyi) Prescription on blood glucose,Hb A1c( glycosylated hemoglobin A1c),C-peptide( C-P),glucagon-like peptide( GLP-1),and α-glucosidase activity in GK( Goto-Kakizaki) rats. [Methods]Selected fasting blood glucose( FBG) > 11. 1mmol/L GK rats and randomly divided into groups: model group,Zishen Qinggan( Shuangyi) Prescription low dosage( ig,400 mg/kg/d),medium dosage( ig,800 mg/kg/d),and high dosage groups( ig,1600 mg/kg/d),and metformin group(ig,85 mg/kg/d). After continuous administration for 28 d,fasting blood glucose(FBG),oral glucose tolerance test(OGTT),Hb A1 c,C-P,GLP-1 and α-glucosidase activity were detected. [Results] Compared with the control group,FBG and Hb A1 c of the model group was significantly higher( P < 0. 01); compared with the model group,Zishen Qinggan( Shuangyi) Prescription could significantly reduce the levels of blood glucose,Hb A1 c,and the elevated blood glucose levels after 120 min of glucose loading in OGTT( P < 0. 05,P < 0. 01),and also can significantly improve the level of C-P,GLP-1( P < 0. 05,P < 0. 01),reduce Homa-IR,and inhibit α-glucosidase activity. [Conclusions]Zishen Qinggan( Shuangyi) Prescription can effectively reduce the blood glucose of GK rats,the action mechanism of which is possibly that it can improve insulin resistance,increase GLP-1 content and inhibit α-glucosidase activity.

[Objective] To study the effects of Zishen Qinggan (Shuangyi) Prescription on blood glucose, Hb A1c (glycosylated hemoglobin A1c), C-peptide (CP), glucagon- like peptide (GLP- 1), and α-glucosidase activity in GK (Goto-Kakizaki) rats. [Methods] Selected fasting blood glucose (FBG)> 11. 1 mmol / L GK rats and randomly divided groups: model group, Zishen Qinggan (Shuangyi) and high dosage groups (ig, 1600 mg / kg / d), and metformin group (ig, 85 mg / kg / d) [Results] Compared with the control group, FBG and Hb A1 c of the d, fasting blood glucose (FBG), oral glucose tolerance test (OGTT), Hb A1 c, CP, GLP-1 and α-glucosidase activity were detected. The model group was significantly higher (P <0.01); compared with the model group, Zishen Qinggan (Shuangyi) Prescription could significantly reduce the levels of blood glucose, Hb A1 c, and the elevated blood glucose levels after 120 min of glucose loading in OGTT (P <0.05, P <0.01), and also could significantly improve the level of CP, GLP-1 (P <0.05, P <0.01) α-glucosidase activity. [Conclusions] Zishen Qinggan (Shuangyi) Prescription can effectively reduce the blood glucose of GK rats, the action mechanism of which is possibly that it can improve insulin resistance, increase GLP-1 content and inhibit α-glucosidase activity.