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目的探讨喜炎平和利巴韦林注射液对手足口病患者血清炎症因子的影响。方法选取该院2014年1—12月收治的120例手足口患儿,随机分作观察组和对照组各60例,对照组患儿单纯给予利巴韦林注射液治疗,观察组在对照组治疗基础上加用喜炎平注射液进行治疗,观察二组患者的治疗效果、并发症情况以及其血清炎症因子变化情况。结果治疗后二组患儿的血清IL-6、TNF-α、IL-2和IL-10细胞因子水平均显著降低,但观察组患儿炎症因子水平下降情况显著优于对照组,差异均有统计学意义(P<0.05);观察组的肠道病毒阴性率(85%)显著高于对照组(65%),观察组总有效率为96.7%,显著高于对照组的81.6%,上述比较差异均具有统计学意义(χ2=6.400,6.9878,P<0.05);治疗后观察组的临床症状变化优于对照组(P<0.05),二组患儿的并发症发生率差异无统计学意义(P>0.05)。结论喜炎平注射液联合利巴韦林注射液治疗婴幼儿手足口病,能够显著缩短治疗时间,降低患儿痛苦,且治愈率高,治疗效果显著,并发症发生率低,无不良反应,具有较高的安全性,显著优于单纯使用利巴韦林注射液治疗,值得临床推广应用。
Objective To investigate the effect of Xiyanping and Ribavirin Injection on Serum Inflammatory Factors in Hand-Foot-Mouth Disease Patients. Methods A total of 120 children with HFMD treated in our hospital from January to December 2014 were randomly divided into observation group (60 cases) and control group (60 cases). The control group was treated with ribavirin injection only. The observation group On the basis of the treatment, Xiyanping injection was used to treat the patients. The therapeutic effects, complications and changes of serum inflammatory cytokines in the two groups were observed. Results After treatment, the serum levels of IL-6, TNF-α, IL-2 and IL-10 in the two groups were significantly decreased, but the levels of inflammatory cytokines in the observation group were significantly better than those in the control group (85%) in the observation group was significantly higher than that in the control group (65%). The total effective rate in the observation group was 96.7%, which was significantly higher than that in the control group (81.6%). The above-mentioned (Χ2 = 6.400,6.9878, P <0.05). After treatment, the changes of clinical symptoms in observation group were better than those in control group (P <0.05). There was no significant difference in the incidence of complications among the two groups Significance (P> 0.05). Conclusion Xiyanping injection combined with ribavirin injection for the treatment of infantile hand, foot and mouth disease can significantly shorten the treatment time, reduce the pain of children, and the cure rate is high, the treatment effect is significant, the incidence of complications is low, no adverse reactions, Has a higher safety, significantly better than the simple use of ribavirin injection treatment, it is worth promoting the clinical application.