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目的:对甲状腺功能亢进症患者发生糖耐量及胰岛素抵抗的情况进行研究和分析。方法:选取2010年3月至2012年6月期间我院收治的130例甲亢患者作为观察组,其中有46例男性患者,82例女性患者,其年龄为19-66岁,其BMI为(22.9±2.8)kg/m2;选取在我院门诊进行体检的84例健康人作为对照组,其中包括24例男性患者,60例女性患者,其平均年龄为(40.2±10.7)岁,BMI为(22.8±3.0)kg/m2。比较两组患者FT3、FT4、HOMA-IS等指标。结果:两组患者FPG、FINS和HOMA-IS指标没有显著的差异(P>0.05);观察组患者的2hPG、2hINS及HOMA-IR指标明显高于对照组患者(P<0.05);观察组患者的ISI指标明显低于对照组患者(P<0.05)。在观察组患者中,有68例(52.31%)患者出现了糖耐量减退情况。结论:有50%以上的甲亢患者存在胰岛素抵抗和糖代谢异常。
Objective: To investigate the incidence of impaired glucose tolerance and insulin resistance in patients with hyperthyroidism. Methods: A total of 130 hyperthyroidism patients admitted to our hospital from March 2010 to June 2012 were selected as the observation group. Among them, 46 patients were male patients and 82 female patients were aged 19-66 years. The BMI was (22.9) ± 2.8) kg / m2. Eighty-four healthy subjects, including 24 males and 60 females, were enrolled in our hospital. The average age was (40.2 ± 10.7) years and the BMI was (22.8) ± 3.0) kg / m2. FT3, FT4, HOMA-IS and other indicators were compared between the two groups. Results: There was no significant difference in FPG, FINS and HOMA-IS between the two groups (P> 0.05). The indexes of 2hPG, 2hINS and HOMA-IR in the observation group were significantly higher than those in the control group (P <0.05) The ISI index was significantly lower than that of the control group (P <0.05). In the observation group of patients, 68 patients (52.31%) patients with impaired glucose tolerance. Conclusion: There are more than 50% hyperthyroidism patients with insulin resistance and abnormal glucose metabolism.