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近年来,世界范围内肿瘤的发病率及其增长速度逐年提升,细胞间隙连接通讯在肿瘤的发生、侵袭和转移中具有极其重要的作用,其通讯功能的正常与否与间隙连接蛋白Cx43的表达水平直接相关,以Cx43为靶点,通过提高Cx43表达水平来实现抑制肿瘤发生、侵袭和转移的中药提取物、中药方剂、生物制剂已有零星报道。药物是通过何种机制调节细胞Cx43的生成、转运和激活其功能,尚不明确,该文对于间隙连接蛋白Cx43在肿瘤发生发展中的作用做一综述。
In recent years, the worldwide incidence of cancer and its growth rate increased year by year, cell gap junctional communication plays an extremely important role in tumorigenesis, invasion and metastasis, and its communication function is normal or not and the expression of connexin Cx43 Level is directly related to Cx43 as a target, by increasing the expression level of Cx43 to achieve inhibition of tumorigenesis, invasion and metastasis of Chinese herbal extracts, traditional Chinese medicine prescriptions, biological agents have been sporadic reports. The mechanism by which the drug regulates the generation, transport and activation of Cx43 in cells is unclear. The role of connexin Cx43 in tumorigenesis is reviewed.