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目的探讨左旋氨氯地平和培哚普利联合应用对2型糖尿病并发高血压及新发肾功能损害患者的疗效。方法我院自2010年1月~2012年12月间收治了确诊为2型糖尿病并发高血压和新发肾功能损害患者60例,并将其进行随机平均的分组,分成三组,每组20例,分别进行左旋氨氯地平、培哚普利、左旋氨氯地平和培哚普利联合的治疗,第一组给予左旋氨氯地平2.5mg,第二组给予培哚普利4.0mg,第三组给予左旋氨氯地平2.5mg和培哚普利4.0mg,三组患者进行为期10周的治疗,对于治疗前后患者的血压和相关肾功能指标进行测量,对于治疗前后三组的结果进行对于分析。结果三组在进行治疗之后血压都有明显的降低,而且尿蛋白的含量有明显的下降,但是两者结合进行治疗对于血压和尿蛋白含量的降低程度要比单独进行一种药物治疗的程度大,两种药物一起使用能够使得效果加倍。结论左旋氨氯地平和培哚普利都有降低血压,降低尿蛋白含量的作用,能缓解新发肾功能损害程度,但是两种药物进行结合治疗的效果会加倍,在临床上可以进行推广应用。
Objective To investigate the efficacy of combination of levamlodipine and perindopril in patients with type 2 diabetes complicated with hypertension and nephropathy. Methods From January 2010 to December 2012, 60 cases of type 2 diabetes complicated with hypertension and nephropathy were randomly divided into three groups (20 in each group) Cases, respectively, levamlodipine, perindopril, levamlodipine and perindopril combination therapy, the first group was given levamlodipine 2.5mg, the second group was given perindopril 4.0mg, the first group Three groups were given levamlodipine 2.5mg and perindopril 4.0mg, three groups of patients for a period of 10 weeks of treatment, before and after treatment for patients with blood pressure and related renal function indicators were measured for the treatment before and after the results of the three groups for analysis. Results After the treatment, the blood pressure of the three groups decreased obviously, and the content of urinary protein decreased obviously. However, the combination of both of them reduced the blood pressure and urinary protein content more than the single drug treatment Both drugs work together to double the effect. Conclusions Both L-amlodipine and perindopril have the effect of lowering blood pressure and reducing urinary protein content, which can relieve the degree of new-onset renal dysfunction. However, the combination of the two drugs will double the effect and be clinically applicable .