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目的 :探讨开展乳腺癌前哨淋巴结活检 (sentinellymphnodebiopsy ,SLNB)的必要性、可行性、准确性及临床应用价值 .方法 :对 4 5例临床、B超及钼靶检测腋窝LN阴性的原发乳腺癌患者 ,术中在原发肿瘤周围注射专利蓝进行腋窝淋巴结切除 (SLNB) ,随后行腋窝淋巴结清扫 (ALND) .术中对部分SLN ,术后对全部LN行常规病理检查 .结果 :4 5例患者中 4 1例检测到SLN ,成功率 91 1% ;假阴性率为 2 4 % ,SLNB总的敏感性是 93 3% ,特异性是 96 1% ;总的阳性和阴性预测值分别是 93 3%和 96 1% .结论 :SLNB能够准确的预测腋窝淋巴结的转移情况 ,保证腋窝淋巴结分期的准确性
Objective: To investigate the necessity, feasibility, accuracy and clinical value of sentinel lyhnode biopsy (SLNB) for breast cancer.Methods: 45 cases of primary breast cancer with LN-negative axillary lymph nodes Patients underwent intraoperative axillary lymph node dissection (SLNB) with patent blue injected around the primary tumor followed by axillary lymph node dissection (ALND) .All patients underwent routine pathological examination of some SLNs and all postoperative LNs.Results: The SLN was detected in 41 of 41 patients, with a success rate of 91.1%, a false negative rate of 24%, a total SLNB sensitivity of 93.3% and a specificity of 96.1%. The overall positive and negative predictive values were 93 3% and 96 1% respectively.Conclusion: SLNB can accurately predict the metastasis of axillary lymph nodes and ensure the accuracy of axillary lymph node staging