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本文对鹤草酚的急性毒性实验指出,小鼠口服LD_(50)为599.8毫克/公斤,油、洒和蓖麻油增加该药毒性,该药引起蛔虫兴奋,因此提出,在服用该药时,忌服大量油酒类食物、避免用蓖麻油作致泻剂和先驱蛔虫后驱绦虫为宜的看法。实验证明,该药对猪肉绦虫囊尾蚴、猪肉绦虫幼虫、短膜壳绦虫和莫氏绦虫均有驱除或杀灭作用,而且对成虫的作用要比对幼虫和囊尾蚴的作用更为敏感。在对短膜壳绦虫和莫氏绦虫作用的比较实验看到,该药比别丁和灭绦灵作用快、海性小、效力高。通过对猪肉绦虫幼虫、莫氏绦虫成虫作用方式的观察和对莫氏绦虫的糖元、虫体代谢及其代谢产物的测定指出,该药驱绦的显著疗效可能是由于该药迅速使绦虫吸盘丧失吸着功能,又全虫急骤挛缩呈痉挛性麻痹状态,致使绦虫脱离肠壁驱于体外;该药杀灭绦虫的原理可能是它显著和持久地抑制虫体细胞代谢,切断维持生命的能量供给所致。
In this paper, the acute toxicity test of apigenin indicated that the oral LD_(50) of mice was 599.8 mg/kg. Oil, sprinkling, and castor oil increased the toxicity of the drug. The drug caused aphid excitability. Therefore, it was suggested that when taking this drug, It is advisable to avoid using large quantities of alcoholic and alcoholic foods, and avoid using castor oil as an antidiarrheal agent and a pioneer locust to drive aphids. Experiments have shown that the drug has a repellent or killing effect on the cysticercus cysticercus, larvae of the larvae, short-shelled shell worms, and moth worms, and is more sensitive to adult worms than larvae and cysticerci. In the comparative experiments on the effects of C. similis and M. sinensis, it was found that the drug had faster effects, less sea water, and higher potency than Bicid and Schizandra. Through the observation of the action mode of the larvae of the aphid larvae and the adult Mothsworm as well as the determination of the metabolites and metabolites of the glycogen and metabolites of Mossella aphid, it was pointed out that the significant effect of the drug repellent may be due to the rapid absorption of the locust by the drug. Loss of sorption function, and the whole insect suddenly collapsed and was paralyzed, causing the aphid to escape from the intestinal wall and drive it in vitro. The principle that the drug kills the aphid may be that it significantly and persistently inhibits the metabolism of the parasite cells and cuts off the life-sustaining energy supply. Caused.